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Chronic Obstructive Pulmonary Disease Pipeline Assets Segmented by Stage, Product Type, Route of Administration, and Molecule Type

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Chronic Obstructive Pulmonary Disease Pipeline Assets Segmented by Stage, Product Type, Route of Administration, and Molecule Type

March 22
05:33 2023
Chronic Obstructive Pulmonary Disease Pipeline Assets Segmented by Stage, Product Type, Route of Administration, and Molecule Type

DelveInsight’s, “Chronic Obstructive Pulmonary Disease Pipeline Insight 2023,” report provides comprehensive insights about 65+ companies and 70+ pipeline drugs in Chronic Obstructive Pulmonary Disease pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

 

For Chronic Obstructive Pulmonary Disease Emerging drugs, the Chronic Obstructive Pulmonary Disease pipeline analysis report provides a 360° view of the therapeutics landscape by development point, product type, route of administration, molecule type, and MOA. The Chronic Obstructive Pulmonary Disease pipeline research covers business opportunities, challenges, future partnerships, strong competitors, and growth strategies.

 

In the Chronic Obstructive Pulmonary Disease Pipeline Report, a detailed description of the drug is given which includes the mechanism of action of the drug, Chronic Obstructive Pulmonary Disease clinical trials studies, Chronic Obstructive Pulmonary Disease NDA approvals (if any), and product development activities comprising the technology, Chronic Obstructive Pulmonary Disease collaborations, licensing, mergers and acquisition, funding, designations, and other product-related details.

 

Key takeaways from the Chronic Obstructive Pulmonary Disease Pipeline Report

 

  • DelveInsight’s Chronic Obstructive Pulmonary Disease Pipeline report depicts a robust space with 65+ active players working to develop 70+ pipeline therapies for chronic obstructive pulmonary disease treatment.

 

  • The leading Chronic Obstructive Pulmonary Disease Companies are working in the market include Sanofi, Chiesi Farmaceutici S.p.A., United Therapeutics Corporation, Verona Pharma plc, Immunotek, Yungjin Pharm. Co., Ltd., Pulmotect, Inc., Tetherex Pharmaceutical, CSL Behring, AstraZeneca, Novartis, Genentech, Vertex Pharmaceuticals, EmeraMed, Afimmune, Mereo BioPharma, Synairgen, Adamis Pharmaceuticals, Quercegen Pharmaceuticals LLC, Regend Therapeutics, Meridigen Biotech Co., Ltd., Pulmatrix, Eisai, GlaxoSmithKline, EpiEndo Pharmaceuticals, 3SBio, OmniSpirant, Foresee Pharmaceuticals, Amgen, Organicell Regenerative Medicine, Arrowhead Pharmaceuticals, ProterixBio, RS BioTherapeutics, MitoRx, C4X Discovery, Respiratorius, ARK biosciences, Incannex, GNI Pharma,   Celon pharma, Alveolus Bio, Kinaset therapeutics, Landos Biopharma, Parion Sciences, KeyMed Biosciences, Bioneer corporation, AlgiPharma, Palobiofarma, Dimerix Bioscience, Glenmark Pharmaceuticals, and others are developing novel drug candidates to improve the chronic obstructive pulmonary disease treatment landscape.

 

  • Promising Chronic Obstructive Pulmonary Disease Pipeline Therapies include SB240563, SAR440340, Dupilumab, CHF 6001, Tyvaso DPI, Ensifentrine, Benralizumab, MV130, YPL 001, PUL-042 Inhalation Solution, SelK2, Batefenterol, Tezepelumab, QBW251, GSK3277511A, Anti-ST2, MEDI3506, Ivacaftor, Emeramide, CSJ117, BCT197, AZD8871, SNG001, APC-1000, Quercetin, CHF6366, Bronchial basal cells, ACT-541468, UMC119-06, PUR1800, Lemborexant, GSK3923868, GRC 39815, EP395, 610, DMX-700,  CM326, LABP-73,  KN-002 and others.

 

  • Chronic Obstructive Pulmonary Disease Companies and academics are working to assess challenges and seek opportunities that could influence Chronic Obstructive Pulmonary Disease R&D. The Chronic Obstructive Pulmonary Disease pipeline therapies under development are focused on novel approaches to treat/improve Chronic Obstructive Pulmonary Disease.

 

Request a sample and discover the recent breakthroughs happening in the Chronic Obstructive Pulmonary Disease Pipeline landscape @ Chronic Obstructive Pulmonary Disease Pipeline Outlook Report

 

Chronic Obstructive Pulmonary Disease Overview

Chronic obstructive pulmonary disease (COPD) is a common, preventable, and treatable disease. It is a poorly reversible lung disease characterized by persistent and progressive airflow limitation caused by an enhanced chronic inflammatory response in the airways and the lungs due to noxious particles or gases. Also, the Global Initiative for Chronic Obstructive Lung Disease (GOLD) defines a COPD exacerbation as an event in the natural course of the disease that is characterized by a change in the patient’s baseline dyspnea, cough, and sputum that is beyond normal day-to-day variations, is acute in onset, and warrants a change in regular medication. Predominantly, COPD includes emphysema and chronic bronchitis.

 

Recent Developmental Activities in the Chronic Obstructive Pulmonary Disease Treatment Landscape

  • In June 2022, the US Food and Drug Administration assigned an Investigational New Drug application (IND) number to Therapeutic Solutions International experimental JadiCell therapy. The FDA has not yet approved the company’s IND application.

 

  • In June 2022, Verona Pharma announced completion of the patient enrolment – with more than 800 subjects involved – for its randomised ENHANCE-1 trial The study will evaluate ensifentrine for the maintenance treatment of chronic obstructive pulmonary disease . It is a critical step for the phase III ENHANCE trial with top-line data expected by the end of the year and further data from ENHANCE-2 in the third quarter of 2022.

 

  • In May 2022, RS BioTherapeutics entered into a license agreement with Synthonics, Inc. for the exclusive, worldwide right to use Synthonics’ metal coordinated cannabinoid in nebulized form for the treatment of pulmonary inflammatory disorders. RS BioTherapeutics is developing its lead compound, RSBT-001, as both an alternative and a complement to corticosteroids for the treatment of chronic obstructive pulmonary disease.

 

  • In March 2022, Pulmatrix, Inc., announced positive top-line results of its recently completed Phase Ib clinical study of PUR1800, a narrow-spectrum kinase inhibitor (NSKI) administered as a dry powder for inhalation with iSPERSE  for evaluation in patients with stable Chronic Obstructive Pulmonary Disease (COPD). PUR1800 is being developed to treat Acute Exacerbations in Chronic Obstructive Pulmonary Disease (AECOPD). Initial safety and pharmacokinetics (PK) were evaluated in patients with stable COPD.

 

  • In September 2021, Renovion and the COPD Foundation announced the creation of a new partnership to accelerate the development of a novel therapy for the treatment of excessive airway mucus and inflammation in individuals with chronic obstructive pulmonary disease (COPD) and non-cystic fibrosis (CF) bronchiectasis.

 

  • In August 2021, EpiEndo Pharmaceuticals announced the closing of a €20m Series A financing round led by Flerie Invest and Iðunn Venture Fund, with existing investors ABC Ventures participating, along with the European Innovation Council (EIC) Fund joining the round. The financing secures funds to advance clinical development of EpiEndo’s lead compound EP395, which entered phase I clinical trials in April, through Phase IIa, targeting COPD as a primary indication. In May 2022, the company completed its Phase I First Time in Human (FTIH) study with EP395 in healthy subjects.

 

  • In May 2021, vTv Therapeutics LLC entered into an exclusive licensing agreement with Newsoara Biopharma  for rights to develop and commercialize vTv Therapeutics’ PDE4 Inhibitor program in mainland China, Hong Kong, Macau, Taiwan and other Pacific Rim countries covering Thailand, Vietnam, Indonesia, Malaysia, Philippines, Singapore, Myanmar, Cambodia, Laos, Brunei and South Korea.  Under the terms of the agreement, vTv Therapeutics received an upfront payment and will be eligible to receive future development and commercialization milestones as well as royalties on sales of approved products. Newsoara to develop HPP737 in the covered territories for respiratory and other inflammatory diseases, including COPD. 

 

For further information, refer to the detailed Chronic Obstructive Pulmonary Disease Drugs Launch, Chronic Obstructive Pulmonary Disease Developmental Activities, and Chronic Obstructive Pulmonary Disease News, click here for Chronic Obstructive Pulmonary Disease Ongoing Clinical Trial Analysis

 

Chronic Obstructive Pulmonary Disease Emerging Drugs Profile

 

  • Benralizumab: AstraZeneca

Benralizumab is a humanized recombinant monoclonal antibody of the isotype IgG1k immunoglobulin that specifically binds to the alpha chain of the interleukin-5 receptor (IL-5R) expressed on eosinophils and basophils. It inhibits the binding of IL-5 as well as the hetero-oligomerization of the alpha and beta subunits of the IL-5R, thus blocking, signal transduction. Besides, it is an afucosylated IgG, which gives it a high affinity for the FcγRIIIα receptor in natural killer cells, macrophages, and neutrophils. In the TH2-high phenotype, IL-5 presents a central role as it is responsible for eosinophil differentiation, survival, activation, and migration to the lungs. The drug is currently in Phase III stage of its clinical trial evaluation to treat COPD.

 

  • Dupilumab: Sanofi

Dupilumab is a fully human monoclonal antibody of the immunoglobulin G4 subclass that binds to the interleukin-4 (IL-4) receptor, inhibiting the receptor signaling pathways. As an interleukin-4 receptor alpha antagonist, dupilumab inhibits the signaling of pro-inflammatory cytokines, called interleukins (IL) that induce inflammatory and immunological reactions in several atopic or allergic conditions, such as eczema, allergic reactions, and rhinosinusitis. Dupilumab was generated by recombinant DNA technology in Chinese Hamster Ovary cell suspension culture. Dupilumab is under investigation for its potential therapeutic use in chronic obstructive pulmonary disease and is currently in the Phase III stage of development.

 

  • Tezepelumab: Amgen

Tezepelumab (Tezspire) is a first-in-class human monoclonal antibody that works on the primary source of inflammation: the airway epithelium, which is the first point of contact for viruses, allergens, pollutants, and other environmental insults. Specifically, TEZSPIRE targets and blocks TSLP, a key epithelial cytokine that sits at the top of multiple inflammatory cascades and initiates an overreactive immune response to allergic, eosinophilic, and other types of airway inflammation associated with severe asthma. TSLP is released in response to multiple triggers associated with asthma exacerbations, including allergens, viruses, and other airborne particles. Expression of TSLP is increased in the airways of patients with asthma and has been correlated with disease severity. Blocking TSLP may prevent the release of pro-inflammatory cytokines by immune cells, resulting in the prevention of asthma exacerbations and improved asthma control. Tezspire is being developed in collaboration with AstraZeneca and is currently being evaluated in Phase II to treat patients with chronic obstructive pulmonary disease. 

 

  • SNG001: Synairgen

SNG001 boosts antiviral responses in the lungs, has a beneficial effect on lung function, and in more difficult to treat patients, improves asthma control during cold infections. The drug is currently being evaluated in the Phase II stage of development to treat patients with COPD.

 

  • GSK3923868: GlaxoSmithKline

GSK3923868, is a PI4kβ inhibitor in development as a treatment for viral COPD exacerbations. It belongs to the class of antiasthmatics. The drug acts as a 1-phosphatidylinositol-4-kinase inhibitor. Currently, the drug is in Phase I of its clinical trial evaluation for the treatment of chronic obstructive pulmonary disease.

 

Chronic Obstructive Pulmonary Disease Pipeline Therapeutics Assessment

There are approx. 65+ key companies which are developing the therapies for Chronic Obstructive Pulmonary Disease. The companies which have their Chronic Obstructive Pulmonary Disease drug candidates in the most advanced stage, i.e. phase III include, AstraZeneca.

 

Find out more about the Chronic Obstructive Pulmonary Disease Pipeline Segmentation, Therapeutics Assessment, and Chronic Obstructive Pulmonary Disease Emerging Drugs @ Chronic Obstructive Pulmonary Disease Treatment Landscape

 

Scope of the Chronic Obstructive Pulmonary Disease Pipeline Report

 

  • Coverage- Global

 

  • Chronic Obstructive Pulmonary Disease Companies- RemeGen, SynCore Biotechnology, Allarity Therapeutics, Daiichi Sankyo Company, Jiangsu Alphamab Biopharmaceuticals Co., Ltd, Byondis B.V., Jiangsu Hansoh Pharmaceutical Co., Ltd., Shanghai Miracogen Inc., Ambrx, Inc., Daehwa Pharmaceutical Co., Ltd., Phoenix Molecular Designs, Menarini Group, Samus Therapeutics, Inc., Hanmi Pharmaceutical Company Limited, Jiangxi Qingfeng Pharmaceutical Co. Ltd., Immutep Limited, Arvinas Inc., G1 Therapeutics, Mirati Therapeutics Inc., Chia Tai Tianqing Pharmaceutical, Shanghai Pharmaceuticals Holding Co., Ltd, Pfizer, OncoTherapy Science, Inc., Eisai Inc., Dizal Pharmaceuticals, Tyme, Inc, Orion Pharma, HiberCell, Inc., Rhizen Pharmaceuticals SA, Hutchison Medipharma Limited, OncoPep Inc., Taizhou Hanzhong biomedical co. LTD, Kind Pharmaceuticals LLC, Dantari, Inc., Veru Inc., Taiho Oncology, Eli Lilly and Company, Sermonix Pharmaceuticals, Merus N.V., Minerva Biotechnologies Corporation, Kintara Therapeutics, Inc., Sichuan Baili Pharmaceutical Co., Ltd.,  Regor Pharmaceuticals Inc., Tianjin Hemay Biotech, Jiangsu Simcere Pharmaceutical Co., Ltd., and others.

 

  • Chronic Obstructive Pulmonary Disease Pipeline Therapies- Disitamab Vedotin, EndoTAG®-1 (SB05), Stenoparib (2X-121), U3-1402, KN026, trastuzumab duocarmazine, HS-10342, MRG002, ARX788, DHP107, PMD-026, PVX-410, HX008, Tenalisib, MEN1611, SM-88, HMPL-013, ODM-209, HC-5404-FU, RP12146, PU-H71, NOV120101, SC10914, Eftilagimod Alpha, ARV-471, E7090, DZD1516, G1T38, Sitravatinib, TQ-B211, B003, PF-06873600, OTS167PO, AND019, DAN-222, Enobosarm, Futibatinib, LY3484356, Lasofoxifene, MCLA-128, huMNC2-CAR44 CAR T cells, REM-001, GNC-035, RGT-419B, Hemay022, SCR-6852, and others.

 

  • Chronic Obstructive Pulmonary Disease Segmentation: Product Type, Molecule Type, Mechanism of Action, Route of Administration

 

Dive deep into rich insights for drugs for Chronic Obstructive Pulmonary Disease Pipeline Companies and Therapies, click here @ Chronic Obstructive Pulmonary Disease Unmet Needs and Analyst Views

 

Table of Content

  1. Introduction
  2. Executive Summary
  3. Chronic Obstructive Pulmonary Disease Overview
  4. Chronic obstructive pulmonary disease Pipeline Therapeutics
  5. Chronic obstructive pulmonary disease Therapeutic Assessment
  6. Late Stage Products (Phase III)
  7. Benralizumab: AstraZeneca
  8. Drug profiles in the detailed report…..
  9. Mid Stage Products (Phase II)
  10. YPL 001: Yungjin Pharm. Co., Ltd.
  11. Drug profiles in the detailed report…..
  12. Early stage products (Phase I/II)
  13. CHF6366: Chiesi Farmaceutici
  14. Drug profiles in the detailed report…..
  15. Inactive Chronic obstructive pulmonary disease Products
  16. Chronic Obstructive Pulmonary Disease Key Companies
  17. Chronic Obstructive Pulmonary Disease Key Products
  18. Chronic Obstructive Pulmonary Disease Unmet Needs
  19. Chronic Obstructive Pulmonary Disease Market Drivers and Barriers
  20. Chronic Obstructive Pulmonary Disease- Future Perspectives and Conclusion
  21. Chronic Obstructive Pulmonary Disease Analyst Views
  22. Chronic Obstructive Pulmonary Disease Key Companies
  23. Appendix

 

Got Queries? Find out the related information on Chronic Obstructive Pulmonary Disease Mergers and acquisitions, Chronic Obstructive Pulmonary Disease Licensing Activities @ Chronic Obstructive Pulmonary Disease Emerging Drugs, and Recent Trends

 

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